Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthetic beta-Lactam Antibiotics I. Synthesis and Antibacterial Activity of 7-Amino-3-[1-(halo-substituted phenyl)-1H-tetrazole-5-yl]thiomethyl-3-cepheme-4-carboxylic acids

  • Koh, Dong-Soo (Organic Chemistry Lab., Korea Advanced Institute of Science and Technology) ;
  • Park, Sang-Woo (Organic Chemistry Lab., Korea Advanced Institute of Science and Technology) ;
  • Kim, You-Seung (Organic Chemistry Lab., Korea Advanced Institute of Science and Technology)
  • Published : 1987.06.20
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Abstract

The syntheses of mercaptotetrazoles and cephalothin analogs are described. Their in vitro potency was established. The compounds exhibited high antibacterial activity against Gram-positive bacteria and moderate activity against Gram-negative bacteria.

Keywords

References

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Cited by

  1. RECENT DEVELOPMENTS IN TETRAZOLE CHEMISTRY. A REVIEW vol.26, pp.5, 1987, https://doi.org/10.1080/00304949409458050