1, 3-Oxazine화합물로부터 4-Hydroxy-2-Methyl-N-(Cyclohexyl)-2H-1, 2-Benzothiazine-3-Carboxamide-1, 1-Dioxide 의 합성

Synthesis of 4-Hydroxy-2-Methyl-N-(Cyclohexyl)-2H-1, 2-Benzothiazine-3-Carboxamide-1, 1-Dioxide via 1,3-Oxazine Compounds

2-Cyclohexylimino-3-cyclohexyl-5-methyl-4-oxo-2H, 5H-1, 3-oxazino [5,6-C]-1, 2-benzothiazine-6,6-dioxide 2 was hydrolized in d-HCl/$CH_3$CN to give 5-methyl-3-cyclohexyl-2H, 5H-1, 3-oxazino [5, 6-C]-1, 2-benzothiazine-2, 4(3H)-dione 6, 6-dioxide 3 in 82% yield. The alkaline hydrolysis of 3 afforded to 4-hydroxy-2-methyl-N-(cyclohexyl)-2H-1, 2-benzothiazine-3-carboxamide-1, 1-dioxide 4 in 88% yield. On the other hand 3 was synthesized from 4 and ethylchloroformate on the reversed procedure.