약학회지 (YAKHAK HOEJI)
- 제31권3호
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- Pages.154-163
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- 1987
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Daidzein의 항염작용과 그 작용기전에 관한 연구 (I)
Studies on the anti-infiammatory activity and its mechanism of daidzein
초록
Daidzein and its methyl derivatives were synthesized and their anti-inflammatory activities were examined. Daidzein suppressed the carrageenin-induced edema, but its methyl derivatives showed decrease or abolition of the anti-inflammatory effect. Daidzein did not significantly suppress the complete Freund's adjuvant-induced arthritis, and the mixed phlogistics (histamine+serotonin)-induced edema. Daidzein inhibited the leukocyte emigration and protein exudation when it was administered into the CMC pouch at low doses (5,25mg/pouch). Daidzein significantly suppressed the cotton-pellet granuloma formation.
키워드