YAKHAK HOEJI (약학회지)
- Volume 31 Issue 1
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- Pages.1-9
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- 1987
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of Angiotensin Converting Enzyme Inhibitors (II)
안지오텐신 변환효소 억제작용물질의 합성 (II)
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Yun, Hye-Sook
(Natural Products Research Institute, Seoul National University) ;
- Lee, Jong-Ran (Natural Products Research Institute, Seoul National University) ;
- Lee, Hee-Joo (Department of Pharmacy, Duksung Woman's College) ;
- Yun, Sung-Mee (Department of Pharmacy, Duksung Woman's College) ;
- Lee, Sun (Department of Pharmacy, Duksung Woman's College)
- Published : 1987.02.01
Abstract
The preparation of substituted benzoylamino acids and mercaptoacylariaino acids as inhibitors of angiotensin converting enzyme is described. The bulky phenyl ring directly attacted to an amino acid as of benzoylamino acid seemed unsuitable for the inhibitory activities. Among the mercaptosuccinylamino acids, /sub L/-proline was more favorable than /sub L/-phenylalanine while S-acetylation was unfavorable.
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