YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Angiotensin Converting Enzyme Inhibitors (II)

안지오텐신 변환효소 억제작용물질의 합성 (II)

  • Yun, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
  • Lee, Jong-Ran (Natural Products Research Institute, Seoul National University) ;
  • Lee, Hee-Joo (Department of Pharmacy, Duksung Woman's College) ;
  • Yun, Sung-Mee (Department of Pharmacy, Duksung Woman's College) ;
  • Lee, Sun (Department of Pharmacy, Duksung Woman's College)
  • 윤혜숙 (서울대학교 생약연구소) ;
  • 이종란 (서울대학교 생약연구소) ;
  • 이희주 (덕성여자대학교 약학과) ;
  • 윤성미 (덕성여자대학교 약학과) ;
  • 이선 (덕성여자대학교 약학과)
  • Published : 1987.02.01
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Abstract

The preparation of substituted benzoylamino acids and mercaptoacylariaino acids as inhibitors of angiotensin converting enzyme is described. The bulky phenyl ring directly attacted to an amino acid as of benzoylamino acid seemed unsuitable for the inhibitory activities. Among the mercaptosuccinylamino acids, /sub L/-proline was more favorable than /sub L/-phenylalanine while S-acetylation was unfavorable.

Keywords