Archives of Pharmacal Research
- Volume 10 Issue 3
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- Pages.149-152
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- 1987
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Protective Effect of Diallyl Disulfide on Ethacrynic Acid-Inducted Toxicity in Mice
- Huh, Keun (Department of Pharmacy, College of Pharmacy, Yeungnam University) ;
- Lee, Sang-Il (Department of Pharmacy, College of Pharmacy, Yeungnam University) ;
- Song, Jae-Woong (Department of Pharmacy, College of Pharmacy, Yeungnam University)
- Published : 1987.09.01
Abstract
The present work was undertaken to investigate the effect of diallyl disulfide on ethacrynic acid toxicity. Ethacrynic acid-induced morality and formation of lipid peroxide were inhibited by diallyl disulfide. Furthermore, decreasing effect of glutathione S-transferase and glutathione level in the liver by ethacrynic acid were reduced by diallyl disulfide. These results suggested that the inducing effect of diallyl disulfide on the ethacrynic acid metabolizing enzyme, glutathione S-transferase, is believed to be a possible detoxication mechanism for the ethacrynic acid toxicity in mice.