Archives of Pharmacal Research
- Volume 10 Issue 2
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- Pages.100-102
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- 1987
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Inhibition of platelet aggregation by colchicine, thiocolchicine, and their phenolic and glucosidic congeners
- Arnold-Brossi (National Instiute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health) ;
- Raymond-Dumont (National Instiute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health) ;
- Yunchoi, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
- Lee, Jong-Ran (Natural Products Research Institute, Seoul National University)
- Published : 1987.06.01
Abstract
Inhibition of platelet aggregation by colchicine, thiocolchicine, O-demethylated and 3-glucosidic congeners was measured in vitro. 2-And 3-demethylated analogs of colchicine and thiocolchicine were found tobe as potent as colchicine and thiocolchicine, respectively, whereas 1-demethylated compounds were found to be considerably less active. Both glucosides, colchicoside and thiocolchicoside, were not very active in this assay. 2, 3-Didemethylcolchicine, which is much less toxic than colchicine, showed similar inhibitory effects on platelet aggregation as colchicine.