Journal of Pharmaceutical Investigation
- 제17권3호
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- Pages.127-133
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- 1987
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
시판 설프이속사졸정의 용출거동 및 상대 생체이용율
Dissolution Behavior and Relative Bioavailability of Commercially Available Sulfisoxazole Tablets in Humans
- Koh, Ik-Bae (College of Pharmacy, Chonnam National University) ;
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Lee, Yong-Bok
(College of Pharmacy, Chonnam National University)
- 발행 : 1987.09.20
초록
Dissolution characteristics and urinary excreted amount of commercially available three brands of sulfisoxazole tablets were investigated in order to elucidate the in vitro-in vivo correlations and relative bioavailability in humans. All the tablets tested met the K.P. IV and the USP XXI specifications for tablet weight variation, content uniformity, disintegration and dissolution. The disintegration and dissolution rate constants of sulfisoxazole tablets in pH 2.0 HCl-KCl buffer were reduced more significantly (p<0.05) than those in diluted HCl
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