대한약리학회지 (The Korean Journal of Pharmacology)
- 제23권2호
- /
- Pages.151-157
- /
- 1987
- /
- 0377-9459(pISSN)
흰쥐의 Carrageenin 유발 늑막염과 Croton oil 유발 육아종양에 미치는 Cyclobuxine D의 영향
Effects of Cyclobuxine D on Carrageenin-induced Pleurisy and Croton Oil-induced Granuloma Pouch in Rats
- 이종화 (순천향대학 의학부 약리학교실) ;
- 박영현 (순천향대학 의학부 약리학교실) ;
- 조병헌 (순천향대학 의학부 약리학교실) ;
- 김유재 (순천향대학 의학부 약리학교실) ;
- 김종배 (순천향대학 의학부 약리학교실) ;
- 김정목 (순천향대학교 의학부 약리학교실) ;
- 김천숙 (순천향대학 의학부 약리학교실) ;
- 차영덕 (순천향대학 의학부 약리학교실) ;
- 김영석 (순천향대학 의학부 약리학교실)
- Lee, Jong-Hwoa (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Park, Young-Hyun (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Cho, Byung-Heon (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Kim, Yu-Jae (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Kim, Jong-Bae (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Kim, Chung-Mok (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Kim, Chun-Sook (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Cha, Young-Deog (Department of Pharmacology, College of Medicine, Soonchunhyang University) ;
- Kim, Young-Suk (Department of Pharmacology, College of Medicine, Soonchunhyang University)
- 발행 : 1987.12.30
초록
Steroidal alkaloid인 cyclobuxine D의 carrageenin으로 유발한 늑막염과 croton oil로 유발한 육아종양에 대한 영향을 관찰하고 그 작용을 aspirin, dexamethasone과 hydrocortisone의 작용과 비교하였다. Carrageenin으로 유발한 늑막염에서 혈장 삼출정도는 pontamine sky blue을 정맥으로 투여하여 20분 동안 늑막염 삼출물로 삼출되어 나오는 양으로 측정하였다. Cyclobuxine D는 용량적으로 삼출물의 양과 20분 동안 삼출되는 pontamine sky blue의 양을 감소시켰다. Cyclooxygenase 억제제인 aspirin과 phospholipase
Cyclobuxine D, a steroidal alkaloid, was extracted from Buxus microphylla var. koreana Nakai. The effects of cyclobuxine D on carrageenin-induced pleurisy and croton oil-induced granuloma pouch in rats was investigated and compared with those of aspirin, hydrocortisone ana dexamethasone. Intrapleural injection of 2% carrageenin caused the accumulation of exudate. The rate of plasma exudation, measured by the exuded dye amounts for 20 min in the pleural cavity after intravenous injection of pontamine sky blue, showed a peak at 5 hr. Cyclobuxine D (5, 20 and 50 mg/kg, i.p.) suppressed dose-dependently the accumulation of the pleural exudate and the exudation of dye. Among several methods used for screening and evaluation anti-inflammatory agents, granuloma pouch technic introduced by Hans Selye (Hans seyle, 1953) is considered as a simple and reliable method. An air pocket was produced in the subcutaneous tissue of the interscapular region by injection of 1 ml of 1% croton oil as irritant. Inflammatory exudate accumulated in the pouch during the succeding 14 days. Cyclobuxine D (5 and 20 mg/kg) decreased fluid volume in pouch and weight of pouch wall in granulomatous inflammation.