Pathogenesis of Perirenal Edema in Pigs and Rabbits Administered with Oxalate, Nitrate and Calcium

Oxalate, Nitrate 및 Calcium 혼합투여(混合投與)에 의(依)한 돈(豚) 및 가토(家兎)의 Perirenal Edema 발병(發病)

  • Cho, Sung-whan (Department of Veterinary Medicine, College of Agriculture, Chungnam National University) ;
  • Lee, Cha-soo (Department of Veterinary Medicine, College of Agriculture, Kyungpook National University)
  • 조성환 (충남대학교 농과대학 수의학과) ;
  • 이차수 (경북대학교 농과대학 수의학과)
  • Received : 1986.02.28
  • Published : 1986.04.30

Abstract

In order to clarify the pathogenesis of perirenal edema, pigs and rabbits were administered with oxalate and nitrate, with oxalate nitrate and glycolic acid, with oxalate, nitrate and ascorbic acid and with oxalate, nitrate and calcium, respectively. The results obtained are summarized as follows; The pigs and rabbits administered with oxalate and nitrate with oxalate, nitrate and glycolic acid and with oxalate, nitrate and ascorbic acid, respectively, were not showed perirenal edema despite of observing the abundant oxalate crystals in the proximal convoluted tubles. But pigs and rabbits administered with oxalate, nitrate and calcium were histopathologically showed perirenal edema similar to those of pigs fed Amaranthus retroflexus. Therefore, author considered that oxalate, nitrate and calcium are main factors to cause perirenal edema. It was regarded that perirenal edema in pigs was caused by the reciprocal reactions of those materials including oxalate, nitrate and calcium which may produce vascular damage, decreased osmotic pressure by hypoproteinemia and increased vascular permeability in kidney, rather than the mechanical obstructions by the oxalate crystals in the proximal convoluted tubule.

Keywords