Journal of Yeungnam Medical Science
- Volume 3 Issue 1
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- Pages.279-285
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- 1986
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- 2799-8010(eISSN)
Effect of Carbamazepine on the Ouabain-Induced Arrhythmia in Rabbits
가토의 Quabain-Induced Arrhythmia에 미치는 Carbamzepine의 효과
- Kim, Eui-Hong (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Ha, Jeoung-Hee (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Lee, Kwang-Youn (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Kim, Won-Joon (Department of Pharmacology College of Medicine, Yeungnam University)
- Published : 1986.06.30
Abstract
Carbamazepine is a derivative of iminostilbene with carbamyl group and related chemically to the tricyclic antidepressants. Carbamazepine has been introduced for treatment of trigeminal neuralgia. Recently it is used as an antiepileptic agent such as diphenylhydantoin. Antiepileptic drugs are known to affect experimentally induced cardiac arrhythmia and are now widely used clinically for treatment of ventricular tachyarrhythmias, particularly those produced by digitalis intoxication. Steiner et al.(1970) reported that carbamazepine was found to be very effective in converting ventricular tachycardia due to digitalis toxicity to normal sinus rhythm. Clinically bradycardia, complete heart block, ventricular standstill and Adams-stokes attack were reported in the course of carbamazepine treatment. The purpose of this study was to investigate the effects of carbamazepine on the ouabain-induced arrhythmia in vivo. The rabbits of either sex, weighing from 1.6 to 3.2kg were anesthesized by urethane. After the trachea was cannulated, the rabbits were ventilated with room air using a respirator. Drugs were given into polyethylene cannula in the femoral vein. Blood pressure were recorded by physiograph via pressure tranducer connected with the cannula in the femoral artery. EKG were recorded by Physiograph via electrode implanted in both fore leg and left hind leg. The results are summarized as follows; 1. Arrhythmia was induced by continuous infusion of ouabain.(
가토의 Ouabain유발 부정맥에 미치는 Carbamazepine의 영향을 검색한 결과 다음과 같은 결론을 얻었다. 1. Ouabain을 지속적으로 정맥 주사하여 64+
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