Journal of Yeungnam Medical Science
- 제3권1호
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- Pages.229-235
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- 1986
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- 2799-8010(eISSN)
Lithium 이온의 배설에 미치는 Corticosteroid의 영향
Effect of Corticosteroids on Renal Excretion of Lithium
- Oh, Shin-Yul (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Ha, Jeoung-Hee (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Lee, Kwang-Youn (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Kim, Won-Joon (Department of Pharmacology College of Medicine, Yeungnam University)
- 발행 : 1986.06.30
초록
rat에 주사된 lithium 이온의 배설에 미치는 수종의 corticosteroid의 영향을 검색한 결과 다음과 같은 결론을 얻었다. 1. fludrocortisone을 10mg/kg 투여하여 혈청내 lithium 농도를 줄일 수 있었고, lithium의 뇨중 배설량도 증가시켰다. 2. dexamethasone을 0.1mg/kg 투여하여 혈청내 lithium 농도를 줄일 수 있었고, 1mg/kg을 투여하여 lithium의 뇨중 배설량도 증가시켰다. 3. dexamethasone에 의하여서는 혈중
Lithium salts are being used increasingly to treat patient with affective disorders, especially acute mania, or bipolar manic-depressive illness. For therapeutic effect the lithium content must be maintained at or above a particular level. Lithium poisoning due to overdosage may be seen occasionally, and its course is determined primarily by the rate of renal lithium elimination. A search is therefore indicated for procedures that could raise the lithium clearance. In a number of reports renal lithium excretion has been studied in relation to the excretion of water, sodium, potassium and hydrogen, but effects of sodium or water on the lithium excretion has not yet been clarified. Hence the present study was undertaken to investigate the effects of corticosteroid on the excretion of lithium ion. The female rat(Sprague-Dowley), weighing from 200 to 300g, was injected with 50mg/kg of lithium chloride intraperitoneally, and then injected with graded dosage of fludrocortisone and dexamethasone in each group. During the injected rats were incubated in metabolic cage, 24 hour urine of rats were collected. At 24 hours after injection, the rats were sacrificed with guillotin, the blood were collected. And then the concentratios of
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