The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
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Study on the Genetic Relationship between Korean Hemorrhagic Fever, Chronic Hepatitis and Histocompatibility Antigens(II) -(II) Study on the Genetic Relationship between Chronic Hepatitis and Histocompatibility Antigens-

한국형 출혈열 및 만성간염과 조직적합성 항원간의 유전적 관련성에 관한 연구(II) -(II) 만성간염과 조직적합성 항원간의 유전적 관련성에 관한 연구-

  • Han, Hoon (Department of Microbiology, Catholic Medical College) ;
  • Kim, Tae-Kyu (Department of Microbiology, Catholic Medical College) ;
  • Rhyu, Moon-Gun (Department of Microbiology, Catholic Medical College) ;
  • Lim, Byung-Uk (Department of Microbiology, Catholic Medical College) ;
  • Kim, Gum-Ryong (Department of Microbiology, Catholic Medical College) ;
  • Lee, Chong-Hoon (Department of Microbiology, Catholic Medical College) ;
  • Kim, Boo-Sung (Department of Internal Medicine, Catholic Medical College) ;
  • Kim, Ho-Youn (Department of Internal Medicine, Catholic Medical College) ;
  • Yoon, Young-Suk (Department of Internal Medicine, Catholic Medical College) ;
  • Bang, Byung-Kee (Department of Internal Medicine, Catholic Medical College) ;
  • Min, Byong-Sok (Department of Internal Medicine, Catholic Medical College) ;
  • Kim, Han-Hua (Department of Biology, Catholic Medical College) ;
  • Park, Hee-Bong (Department of Internal Medicine, Chung Goo Sung Sim Hospital)
  • 한훈 (가톨릭의과대학 미생물학교실) ;
  • 김태규 (가톨릭의과대학 미생물학교실) ;
  • 유문간 (가톨릭의과대학 미생물학교실) ;
  • 임병욱 (가톨릭의과대학 미생물학교실) ;
  • 김금용 (가톨릭의과대학 미생물학교실) ;
  • 이종훈 (가톨릭의과대학 미생물학교실) ;
  • 김부성 (가톨릭의과대학 내과학교실) ;
  • 김호연 (가톨릭의과대학 내과학교실) ;
  • 윤영석 (가톨릭의과대학 내과학교실) ;
  • 방병기 (가톨릭의과대학 내과학교실) ;
  • 민병석 (가톨릭의과대학 내과학교실) ;
  • 김한화 (가톨릭의과대학 생물학교실) ;
  • 박희봉 (청구성심병원 내과)
  • Published : 1986.06.30
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Abstract

Patients of chronic hepatic diseases(n=107) including chronic hepatitis caused by hepatitis B virus infections(n=31), liver cirrhosis(n=53), and hepatocellular carcinoma(n=23) were examined to ascertain genetic relationship between chronic hepatic diseases and histocompatibility antigen. Peripheral blood lymphocytes were separated from whole blood by the method of Ficoll/Hypaque gradient. Total 54 histocompatibility antigens(class I antigens: 41, class II antigens: 13) were analysed by performing of complement dependent microlymphocytotoxicity method using Terasaki's and Catholic Medical College tissue typing plates. HLA antigen frequencies were compared with those of 661 normal controls. The following results were obtained: 1. HLA antigen frequencies of HLA-Bw46, -Bw76, -Cw1, -Cw6, and HLA-DR8 in chronic hepatitis patients were shown to be higher than those in controls(P<0.01). 2. HLA antigen frequencies of HLA-Bw46, -Cw7(P<0.01), and HLA-B37, -Bw58, -Cw1, -MT1(P < 0.05) in liver cirrhosis patients were shown relatively higher frequencies than those in controls. 3. In patients with hepatocellular carcinoma, antigens of HLA-A1, -A26, -Cw3, -Cw7 and HLA-DR6 were dominantly detected. 4. There were negative associations with HLA-Cw4, and -DR4 in patients of chronic hepatic diseases(P < 0.05).

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