대한미생물학회지 (The Journal of the Korean Society for Microbiology)

대한미생물학회 (The Korea Society for Microbiology)
권호 표지

Salmonella typhimurium에 대한 마우스 지연성 과민반응의 입양전달

Adoptive Transfer of Delayed-Type Hypersensitivity to Salmonella typhimurium in Mice

  • 이헌구 (전북대학교 의과대학 미생물학교실) ;
  • 장현철 (전북대학교 대학원 의학과) ;
  • 한장연 (전북대학교 대학원 의학과) ;
  • 하대유 (전북대학교 의과대학 미생물학교실)
  • Lee, Hern-Ku (Department of Microbiology, Chonbuk National University Medical School) ;
  • Chang, Hyun-Chul (Chonbuk National University Medical School) ;
  • Han, Jang-Yun (Chonbuk National University Medical School) ;
  • Ha, Tai-You (Department of Microbiology, Chonbuk National University Medical School)
  • 발행 : 1986.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was undertaken to investigate to know whether spleen and lymph node cells from immunized mice can transfer systemically the delayed-type hypersensitivity(DTH) reaction to Salmonella typhimurium and to characterize the lymphoid cells using glass, nylon wool and rabbit anti-mouse thymocyte serum. Mice, C57BL/6 or ICR, were immunized subcutaneously at 11, 8 and 2 days before adoptive systemic transfer with $100{\mu}g$ of protein antigen from S. typhimurium in complete Freund adjuvant. It was found that DTH reaction to S. typhimurium could be transferred to normal recipient systemically by both spleen and lymph node cells($10^8\;cells$, respectively) from immunized mice. The cells responsible for this transfer of DTH reaction were glass nonadherent T lymphocytes.

키워드