Kinetic and Equilibrium Studies on Complex Formation Between Ni(II) and D-Penicillamine in Aqueous Media

Ni(II)와 D-Penicillamine과의 착물형성반응에 대한 속도론적 및 평형에 관한 연구

  • Yong-Kyu Kim (Department of Chemistry, Pusan National University) ;
  • Sung-Nak Choi (Department of Chemistry, Pusan National University)
  • 김용규 (부산대학교 자연대학 화학과) ;
  • 최성락 (부산대학교 자연대학 화학과)
  • Published : 1986.10.20

Abstract

Rates and equilibriurn of complex formation between $Ni^{2+}$ and D-penicillamine have been investigated in aqueous solutions. Kinetic study on the complex formation were performed in the pH range of 8∼9 by the use of pressure-jump technique. D-Penicillamine coordinates to the nickel(II) ion utilizing sulfur and nitrogen as donor atoms in the high pH condition (pH 9.2). However, in the pH range of 8.25∼9.07, the stepwise stability constant becomes drastically reduced and the undissociated mercapto group does not participate in bonding. The rate-determining step of the complexation reaction is found to be the release of a water molecule from the inner-coordination sphere of $Ni^{2+}$ ion.

$Ni^{2+}$와 D-penicillamine사이의 착물형성반응에 대한 반응속도 및 평형에 관한 수용액중에서 실시하였다. 속도론적 실험은 압력-급변법을 사용하여 pH8~9범위에서 실시하였다. D-Penicillamine은 질소와 유황원자를 주게로 하여 pH>9.2조건에서 $Ni^{2+}$이온에 배위하나 pH값 8.25∼9.07범위에서 총괄 안정도 상수값이 급격히 감소하며 비해리된 mercapto기가 결합에 참여하지 않는 것으로 밝혀졌다. 또한 이 착물 형성반응에 있어 율속단계는 $Ni^{2+}$이온의 내부 배위권으로 부터 물분자가 유리되는 과정임이 밝혀졌다.

Keywords

References

  1. Am. J. Med. v.21 J.M. Walshe
  2. Science v.128 H.V. Aposhine
  3. Arch. Biochem. Biophys. v.97 E.J. Kuchinskas;Y. Rosen
  4. Biochem. v.3 G.R. Lenz;A.E. Martell
  5. Technique of Organic Chemistry v.VII M. Eigen;L. Demaeyer;S.L. Friess(ed.)
  6. Z. Elektrochem. v.66 M. Eigen;K. Tamm
  7. Inorg. Chem. v.3 G.H. Nancollas;N. Sutine
  8. J. Inorg. Nucl. Chem. v.33 Darr;G.Macri;S. Petrucci
  9. Bull. Chem. Soc. Jpn. v.45 S. Harada;K.Amidaiji;T. Yasunaga
  10. Bunsenges. Physik. Chem. v.73 M. Hoffmann
  11. Bunsenges. Physik. Chem. v.72 U. Nickel;H. Hoffmann;W.Jaenicke
  12. Wogel's Textbook of Quantitative Inorganic Analysis J. Bassett;R.C. Denney;G.H. Jeffery;J. Mendha
  13. Metal Amine Formation in Aqueous Solutions J. Bjerrum
  14. J. Chem. Soc. H. Irving;H.S. Rossotti
  15. Biochem. J. v.47 A. Albert
  16. Biochem. J. v.50 A. Albert
  17. J. Amr. Chem. Soc. v.77 N.C. Li;R.A. Manning
  18. J. Chem. Soc. C.W. Davis
  19. J. Phys. Chem. v.69 F. P. Cavasino
  20. J. Am. Chem. Soc. v.80 R. Fuoss
  21. Z. Elektrochem. v.64 M. Eigen
  22. J. Chem. Phys. v.37 T.J. Swift;R.E. Connik
  23. Inorg. Chem. Acta. v.6 A. Gergely;I. Sovago;I. Nagypal
  24. J. Chem. Soc. (A) D.D. Perrin;I.G. Sayce
  25. J. Inorg. Nucl. Chem. v.32 P.J. Morris;R.B. Martine