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Synthesis of (E,E)-2,4-Dienols from (E)-$\beta$-Chloro-$\gamma$-hydroxy-vinylmercurials and Olefins by Palladium(Ⅱ) Salt

  • Kim, Jin-Il (Department of Industrial Chemistry, Hanyang University) ;
  • Lee, Jong-Tae (Department of Industrial Chemistry, Hanyang University) ;
  • Choi, Cheol-Kyu (Department of Industrial Chemistry, Hanyang University)
  • Published : 1986.06.20

Abstract

Reaction of $(E)-{\beta}-chloro-{\gamma}$-hydroxyvinylmercurials, prepared by mercuration of propargyl alcohol and 2-methyl-3-butyne-2-ol, with olefins in the presence of a catalytic amount of $Li_2PdCl_4$ and 2 equiv of cupric chloride in methanol at $50^{\circ}C$ gave the corresponding (E,E)-2,4-dienols in moderate yields. However, addition of 1 equiv of inorganic bases such as magnesium oxide to the reaction mixture brings a rapid and clean vinylation and gave high yields of the dienols at room temperature. In the case of hindered (E)-2-chloro-3-chloromercuri-2-buten-1,4-diol prepared from 2-butyne-1,4-diol, reaction with olefins gave the dienols only in low yields even in the presence of 2 equiv of magnesium oxide.

Keywords

References

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Cited by

  1. Tin-Free Three-Component Coupling Reaction of Aryl Halides, Norbornadiene (or Norbornene), and Alkynols Using a Palladium Catalyst vol.23, pp.1, 1986, https://doi.org/10.5012/bkcs.2002.23.1.112