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Synthesis of a Conformationally-rigid Etorphine Analogous

  • 발행 : 1986.06.20

초록

In order to synthesize conformationally rigid etorphine analogues having potentially interesting pharmacological activities, synthesis of compound 3 by the reaction of compound 4 and compound 5 via intramolecular Diels-Alder reaction has been attempted. However, the reaction did not go well and the compound 3 would not be isolated. Therefore, intermolecular Diels-Alder reaction using dimethyl acetylene dicarboxylate was attempted. As shown in scheme 2, Diels-Alder adduct 9 was converted into the target molecule 14 containing the new [2.2.2] bicyclo octane ring in good yields.

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참고문헌

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피인용 문헌

  1. N-Demethylation of Alkaloids vol.1, pp.10, 1986, https://doi.org/10.1177/1934578x0600101008