대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)
- 제7권2호
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- Pages.111-112
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- 1986
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- 1229-0807(pISSN)
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- 2288-9396(eISSN)
Development of Hollow Fibers for the Controlled Release of Drugs
- Feijen, J. (Department of Chemical Technology, Twente University of Technology) ;
- Eenink, M.J.D. (Department of Chemical Technology, Twente University of Technology) ;
- Olijslager, J. (Plastics and Rubber Research Institute TNO) ;
- Schakenraad, J.M. (Laboratory of Histology/Centre for Medical Electron Microscopy, University of Groningen) ;
- Nieuwenhuis, P. (Laboratory of Histology/Centre for Medical Electron Microscopy, University of Groningen) ;
- Molenaar, I. (Laboratory of Histology/Centre for Medical Electron Microscopy, University of Groningen)
- 발행 : 1986.12.01
초록
Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100, 300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise.
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