Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Development of Hollow Fibers for the Controlled Release of Drugs

  • Feijen, J. (Department of Chemical Technology, Twente University of Technology) ;
  • Eenink, M.J.D. (Department of Chemical Technology, Twente University of Technology) ;
  • Olijslager, J. (Plastics and Rubber Research Institute TNO) ;
  • Schakenraad, J.M. (Laboratory of Histology/Centre for Medical Electron Microscopy, University of Groningen) ;
  • Nieuwenhuis, P. (Laboratory of Histology/Centre for Medical Electron Microscopy, University of Groningen) ;
  • Molenaar, I. (Laboratory of Histology/Centre for Medical Electron Microscopy, University of Groningen)
  • Published : 1986.12.01
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Abstract

Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100, 300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise.

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