YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Study on Synthesis of Methyl-7-iodoheptanoate

Methyl-7-oidoheptanoate의 합성에 관한 연구

  • 심영섭 (성균관대학교 약학대학) ;
  • 최종욱 (성균관대학교 약학대학) ;
  • 김완주 (성균관대학교 약학대학) ;
  • 박호군 (한국과학기술원 화학부) ;
  • 박영숙 (한국과학기술원 화학부)
  • Published : 1986.12.01
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Abstract

New synthetic method for methyl-7-iodoheptanoate was studied. Methyl-7-iodoheptanoate is important compound in the synthesis codlemone, the sex pheromone of codling moth which doing harm to apple tree significantly, and this compound also be used essentially in the synthesis of prostaglandin derivatives. In previous the methyl-7-iodoheptanoate has been prepared from-7-chloroheptanoic acid as a starting material with disadvantage, since the 7-chloroheptanoic acid is expensive and the process is much complicate. In this paper the method to preparing methyl-7-iodoheptanoate was developed economically by using dihydropyran as a starting material in the course of 5 steps. Hence, methyl-7-iodoheptanoate which can be synthesized by new method studied onthis paper should be very useful compound for preparing codlemone or its acetate which will be used to developing pollution-free insecticides, and for preparing prostaglandin derivatives with advantage.

Keywords

References

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