YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Dose-Dependent Pharmacokinetics of Acetaminophen in the Rat

아세트아미노펜 체내동태의 용량의존성에 관한 연구

  • Published : 1986.12.01
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Abstract

Dose-dependent pharmacokinetics of acetaminophen was studied in the rat. Acetaminophen was injected intravenously at doses of 10, 30, 50, 100 and 200mg/kg to the adult male rats. The well-known dose-dependent pharmacokinetic behavior was found even at 30mg/kg dose. It implies that metabolism of acetaminophen in the liver, probably sulfation, is saturated at very low concentration of acetaminophen. Dosage regimen establishment based on this characteristics would be necessary even at usual does level (300-600mg/day/body).

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References

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