약학회지 (YAKHAK HOEJI)
- 제30권1호
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- Pages.14-23
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- 1986
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
페니토인 제제의 생체이용률에 관한 연구
The Study on the Bioavailability of the Phenytoin Products
초록
This study was conducted to investigate the correlation between the dissolution rates and the bioavailabilities of commercial phenytoin products, and also the correlation between their biovailabilities in rabbits and those in humans. Dissolution test was conducted in pH 9. 0 alkaline borate buffer (0.2M) using basket method with seven phenytoin products commercially available. According to the dissolution rate, the phenytoin products were divided into three groups, such as rapid, intermediate and slow group. Three phenytoin products from each group were selected for the bioavailability test in rabbits and humans. The bioavailability test was carried out in rabbits and normal volunteers using cross over design. Single doses of 20mg/kg and 300mg/man were orally administered to rabbits and normal volunteers respectively. Average
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