Archives of Pharmacal Research
- Volume 9 Issue 3
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- Pages.175-181
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- 1986
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of some organophosphate pesticides on the murine immune system following subchronic exposure 1
-
Moon, Chang-Kiu
(College of Pharmacy, Seoul National University)
;
- Yun, Yeo-Pyo (College of Pharmacy, Seoul National University) ;
- Lee, Soo-Hwan (College of Pharmacy, Seoul National University) ;
- Lee, Young-Soon (College of Veteriniary Medicine, Seoul National University)
- Published : 1986.09.01
Abstract
Four technical grade organophosphate pesticides (Fenitrothion, Fenthion, Dizninon and EPN) were investigated for their effects on the murine immune function. Among the immunotoxicological assay parameters of NIEHS, humoral immune parameter and pathotoxicological indicators were examined in this study. Subchronic exposure of rodents to these pesticides resulted in marked suppression of humoral immune function and moderate histological changes of lymphoid organ any significant alterations of clinical status.