Archives of Pharmacal Research
- Volume 9 Issue 1
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- Pages.25-28
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- 1986
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of certain thiaxanthones as potential schistosomicidal agents
- El-Kerdawy, M.M. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
- El-Eman, A.A. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
- El-Subbagh, H.I. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura)
- Published : 1986.03.01
Abstract
Twenty nine substituted thiaxanthone derivatives were synthesized for schistosomicidal evaluation. The compounds, 1-morpholino-4-methyl-6-nitrothiaxanthone and 1-(2-diethyl-aminoethyl-amino)-4 methyl-6-nitrothiaxanthone dipicrate were found to possess promising schistosomicidal activity against Schistosoma mansoni in mice.
Keywords
- Certain thiaxanthones-syhthesized;
- schistocidal activity evaluated;
- 1-morpholino-4-methy-6-nitrothiaxanthone and 1-(2-diethyl-aminoehty-amino)-4-methyl-6-nirtrothianthone dipicrate- synthesized;
- schistosomicida;
- actibity against Schistiosoma mansoni in mice evaluated