Synthesis of certain thiaxanthones as potential schistosomicidal agents

  • El-Kerdawy, M.M. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
  • El-Eman, A.A. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
  • El-Subbagh, H.I. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura)
  • Published : 1986.03.01

Abstract

Twenty nine substituted thiaxanthone derivatives were synthesized for schistosomicidal evaluation. The compounds, 1-morpholino-4-methyl-6-nitrothiaxanthone and 1-(2-diethyl-aminoethyl-amino)-4 methyl-6-nitrothiaxanthone dipicrate were found to possess promising schistosomicidal activity against Schistosoma mansoni in mice.

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