Radiation Oncology Journal
- 제4권2호
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- Pages.89-97
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- 1986
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
다분할조사에 의한 마우스공장소낭선 세포의 선량반응곡선
Dose- Response Curves of Mouse Jejunal Crypt Cells by Multifractionated Irradiation
- Hong, Seong-Eon (Department of Radiology, College of Medicine, Kyung Hee University) ;
- Ahn, Chi-Yul (Department of Radiology, College of Medicine, Kyung Hee University)
- 발행 : 1986.12.01
초록
Co-60 치료기로 마우스 전신에 다분할조사(단일 2, 3, 4, 5, 8, 10, 12, 16회 분할 조사)후 공장소 낭선세포측정법으로 소낭선세포의 재생능력에 대한 선량반응 곡선을 작성하고, 단일선량생존곡선을 분석하여 다음과 같은 결론을 얻었다. 1) 분할조사회수가 증가함에 따라 생존곡선은 고선량으로 이동하고 경사도는 점차 낮아졌다. 2) 단일선량생존곡선에서 Dq=460 cGy로 비교적 broad shoulder를 가지며 initial slope
Using as assay for jejunal crypt stem cell survival, dose-response curves for the reproductive capacity of crypt stem cells of mouse jejunum exposed to multifractionated gamma-ray irradiation (single, 2, 3, 4, 5, 8, 10, 12, and 16 fractions) were analyzed and single-dose survival curve of these cells was constructed. The following conclusion were drawn: 1) Survival curves for higher numbers of dose fractions were displaced to higher dose, and characterized by increasingly shallower slopes. 2) The single-dose survival curve had broad shoulder, Dq=460 cGy, remaining near-exponential over initial dose range 0 to 300 cGy, with initial slope 1Do=474 cGy. 3) At fractionated dose En the range of 180 to 450 cGy, the average recovered dose per fraction interval was approximately