Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Effect of Terbufos on the Activity of Acetylcholinesterase in the Chicken

Terbufos가 병아리 중(中) Acetylcholinesterase에 미치는 영향(影響)

  • Hong, Jong-Uck (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Kim, Jung-Ho (Department of Environmental Health, Taegu Oriental Medical College) ;
  • Kim, Jang-Eok (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University)
  • 홍종욱 (경북대학교 농과대학) ;
  • 김정호 (대구한의과대학 환경보건학과) ;
  • 김장억 (경북대학교 농과대학)
  • Published : 1986.09.30
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Abstract

The responses of brain acetylcholinesterase(Ach-E) and plasma cholinesterase (Ch-E) activities were studied in chicknes given oral doses of Terbufos(S-tert-butyl thiomethyl 0,0-diethyl phosphorodithioate), an organophosphorus insecticide. The acute oral $LD_{50}$ of terbufos was 1.82mg/kg. The activity of plasma Ch-E was inhibited more rapidly than that of brain Ach-E, whereas recovery of plasma Ch-E activity was more rapid than that of brain Ach-E. Recovery of brain Ach-E and plasma Ch-E was followed the model $Y=a+b(log_{10}X)$. Brain Ach-E activity and plasma Ch-E were inhibited 83% and 94%, respectively, at 60min after administered oral $LD_{50}$. Brain Ach-E and plasma Ch-E was inhibited in vitro by Terbufos

Terbufos가 병아리 중(中) brain Ach-E 및 plasma Ch-E 활성(活性)에 미치는 영향(影響)을 조사한 결과(結果)는 다음과 같았다. Terbufos의 병아리에 대(對)한 급성경구(急性經口) $LD_{50}$은 1.82mg/kg이었다. Brain Ach-E와 plasma Ch-E에 대(對)한 $pI_{50}$과 Ki는 Terbufos$LD_{50}$에서는 Brain Ach-E 활성(活性)이 83%, plasma Ch-E 활성(活性)이 94%가 저해(沮害)되었다.

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