Journal of Pharmaceutical Investigation
- 제16권4호
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- Pages.139-147
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- 1986
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
메칠오렌지에 의한 말레인산클로르페니라민의 분광광도 정량
Spectrophotometric Determination of Chlorpheniramine Maleate with Methyl Orange
초록
A singly charged methyl orange(MO) anion was found to be extracted with chlorpheniramine maleate(CPM) as a 1 : 1 complex in chloroform. Of various solvents, MO-chloroform system gave a yellow color for CPM, while in the absence of CPM, an organic phase showed almost no color. In this way, the spectrophotometric method was investigated for the determination of CPM by solvent extraction. The addition of alcoholic bolic acid solution to the solvent extract gave a higher color stability and transparency at least 5 days, but the extract alone lost its color intensity significantly. CPM is determined by measuring the absorbance of the extracts over a range of
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