Journal of Pharmaceutical Investigation
- 제16권3호
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- Pages.110-117
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- 1986
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
음이온 모델 화합물 아마란스의 담즙배설에 미치는 타우로데옥시콜레이트의 영향
Effect of Sodium Taurodeoxycholate on Biliary Excretion of Amaranth as an Anionic Model Drug in Rats
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Chung, Suk-Jae (College of Pharmacy, Seoul National University)
- 발행 : 1986.09.20
초록
Plasma disappearance of amaranth (AM), a model compound of organic anionic drugs, was retarded by intravenous infusion of taurodeoxycholate (TDC), a representative bile acid, in the rat. Biliary excretion accounted for 30-60% of the systemic excretion of AM. AM seemed to be metabolised in the hepatocyte to form a compound that is excreted more rapidly into the bile than AM itself, considering apparent biliary clearance,
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