Journal of Pharmaceutical Investigation
- Volume 16 Issue 3
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- Pages.101-105
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- 1986
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Water-Soluble Carriers on Water-Absorption and Swelling of Polydimethylsiloxane-5-Fluorouracil Devices
- O, Sung-Il (College of Pharmacy, Chosun University) ;
- Lee, Chi-Young (College of Pharmacy, Chosun University) ;
- Kim, Sung-Ho (College of Pharmacy, Chosun University)
- Published : 1986.09.20
Abstract
The changes of water absorption and surface area of polydimethylsiloxane-5-fluorouracil devices containing different water soluble additives such as sodium chloride, glycerine, poly-propylene glycol(PPG 400), and polyethylene oxide(PEO 400, 400 and 2000) were investigated. It was confirmed that carriers controlled water absorption and swelling of the devices in the aqueous solutions. The water absorption and the swelling were affected by the osmotic pressure and ionic strength of the aqueous solutions.
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