대한약리학회지 (The Korean Journal of Pharmacology)
- 제22권2호
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- Pages.144-150
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- 1986
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- 0377-9459(pISSN)
흰쥐 간 Glutathione peroxidase 활성에 미치는 Diallyl disulfide의 영향
Effects of Diallyl Disulfide on the Hepatic Glutathione Peroxidase Activity in Rat
- Huh, Keun (Department of Pharmacology, College of Pharmacy, Yeungnam University) ;
- Lee, Sang-Il (Department of Pharmacology, College of Pharmacy, Yeungnam University) ;
- Park, Jong-Min (Department of Pharmacology, College of Pharmacy, Yeungnam University)
- 발행 : 1986.12.30
초록
마늘성분중의 하나인 diallyl disulfide가 간 glutathione peroxidase 활성에 어떠한 영향을 주는가를 관찰하여 다음과 같은 성적을 얻었다. 여러 농도의 diallyl disulfide를 흰쥐에 투여 하였을때 혈청 transaminase의 활성은 변동이 없었으며 또한 간 glutathione의 함량도 변화되지 않았다. 그러나 간 가용성분획의 glutathion peroxidase 활성은 현저히 증가되었다. 시험관 내에서 간 가용성분획의 glutathione peroxidase의 활성은
Glutathione peroxidase might play an important role in the protection of cellular structures against oxidative challange by hydrogen peroxide and several organic hydroperoxides. It is widely accepted that allicin is biological active component of garlic, and allicin is easily degraded to diallyl disulfide and other components. This study was attempted to elucidate the effect of diallyl disulfide on some biological activities. It was observed that the activity of serum transaminase and glutathione level in liver were not changed by the treatment of diallyl disulfide. The liver cytosolic glutathione peroxidase activity was significantly enhanced. Whereas, mitochondrial enzyme activity was slightly increased. In the presence of diallyl disulfide in vitro,