대한미생물학회지 (The Journal of the Korean Society for Microbiology)
- 제20권1호
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- Pages.65-72
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- 1985
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- 0253-3162(pISSN)
Ascorbic acid의 항결핵균 작용에 관한 연구
A Study on Antibacterial Effects of Ascorbic Acid against Mycobacterium tuberculosis
- Kim, Jae-Oh (Department of Microbiology, Kyung Hee University, School of Medicine) ;
- Ho, Soon-Tae (Department of Microbiology, Kyung Hee University, School of Medicine) ;
- Kim, Chan-Soo (Department of Microbiology, Kyung Hee University, School of Medicine)
- 발행 : 1985.12.31
초록
Vitamin C is known as an integral element for the formation and maintenance of intercellular supporting structures. Ascorbic acid has been used for the treatment of certain poisonings and hypovitaminosis(scurvy) but also known as a powerful reducing agent, and can kill a variety of bacteria and detoxify bacterial exotoxins including various clostridial exotoxins in vitro. For viruses, vitamin C inactivates herpes virus, vaccinia virus and influenza virus and has been used for the prevention and treatment of the common cold. Thus ascorbic acid plays an important role in antimicrobial action. Scurvy also promotes the development of tubercles in experimentally infected guinea pig and the tuberculosis patients require more vitamin C than normal persons. However there is no reports that ascorbic acid could inhibit the growh of M. tuberculosis. In this paper, antibacterial effects of ascorbic acid against M. tuberculosis were studied. The results are as follows: 1. The single use of the ascorbic acid exhibited antibacterial effect in vitro against
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