대한핵의학회지 (The Korean Journal of Nuclear Medicine)

대한핵의학회 (The Korean Society of Nuclear Medicine)
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방사 면역측정법에 의한 혈청내 갑상선 유리홀몬 측정의 임상적의의에 대한 기본적 검토

An Assessment of Measurement of Serum Free $T_3,\;T_4$ by Radioimmunoassay

  • 김영훈 (고려대학교 의과대학 내과학교실) ;
  • 이형호 (고려대학교 의과대학 내과학교실) ;
  • 안희권 (고려대학교 의과대학 내과학교실) ;
  • 김숙주 (고려대학교 의과대학 내과학교실) ;
  • 김준석 (고려대학교 의과대학 내과학교실) ;
  • 안일민 (고려대학교 의과대학 내과학교실) ;
  • 이창홍 (고려대학교 의과대학 내과학교실) ;
  • 박승철 (고려대학교 의과대학 내과학교실)
  • Kim, Young-Hun (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Hyung-Ho (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Ahn, Hee-Kwon (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kim, Sook-Joo (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kim, Jun-Suk (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Ahn, Il-Min (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Chang-Hong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Park, Seung-Chull (Department of Internal Medicine, College of Medicine, Korea University)
  • 발행 : 1985.05.20
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초록

The present study was undertaken to examine serum concentration of free $T_3,\;T_4$, in various functional states of the thyroid by Amerlex RIA kit method, which uses unidentified $T_3,\;T_4-labelled$ analogues, said to be unreactive with $T_3,\;T_4-binding$ proteins in serum, together with an antibody that binds both analogue and $T_3,\;T_4$. The test method has been compared with free $T_4$ index, which was product of total serum thyroxine and $T_3$ resin uptake ratio. Free $T_4$ value by this method was found to have a highly significant positive correlation with a free $T_4$ index (r; 0.957, p<0.005) and total $T_4$ (r:0.89, p<0.005) also, it was similar to other free $T_4$ measuring methods previously reported. So, it was showen to have the clinical utility as the screening test for thyroid function because it was a rapid; convinient, and reliable method for quantifying the free $T_4,\;T_3$ concentration in various thyroidal functional states.

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