대한핵의학회지 (The Korean Journal of Nuclear Medicine)
- 제19권1호
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- Pages.95-102
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- 1985
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- 1225-6714(pISSN)
갑상선질환에서 갑상선 자극면역글로불린측정의 의의에 관한 연구 -Micro법 갑상선세포배양에 의한 측정의 기본적 검토-
Thyroid Stimulating Immunoglobulin Bioassay Using Cultured Human Thyroid Cells; A Simplified Micromethod
-
이명철
(서울대학교 의과대학 내과학교실) ;
-
정준기
(서울대학교 의과대학 내과학교실) ;
- 조보연 (서울대학교 의과대학 내과학교실) ;
- 고창순 (서울대학교 의과대학 내과학교실) ;
- 이문호 (서울대학교 의과대학 내과학교실) ;
- 안일민 (고려대학교 의과대학 내과학교실) ;
- 안희권 (고려대학교 의과대학 내과학교실)
-
Lee, Myung-Chul
(Department of Internal Medicine, College of Medicine, Seoul National University) ;
-
Chung, June-Key
(Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Cho, Bo-Youn (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Koh, Chang-Soon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Lee, Mun-Ho (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Ahn, Il-Min (Department of Internal Medicine, College of Medicine, Korea University) ;
- Ahn, Hee-Kwon (Department of Internal Medicine, College of Medicine, Korea University)
- 발행 : 1985.05.20
초록
The activation of adenylate cyclase of human thyrocytes in primary cell culture and the release of c-AMP into the medium are used to detect b-TSH and TSAb in sera of patients with autoimmune thyroid disease. Sera of patients are used directly as a part of cell culture without immunoglobulin precipitation. In the above TSI bioassay, TSAb pooled serum show c-AMP concentration between that of 1mU/ml and 10 mU/ml b-TSH but normal control pooled serum doesn't show any detectable c-AMP response. Ninety fiye percent of untreated Graves' patients shows TSAb activity above normal range, 20% of Hashimoto's and 36% of euthyroid Graves' patients show detectable TSAb activity.
키워드