Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
권호 표지

A Measure of Chemical Carcinogenic Activity for Metal Ions

금속이온에 대한 화학발암성의 척도

  • Byung-Kak Park (Department of Chemistry, College of Science, Yeungnam University) ;
  • Hwhan-Jin Yeo (Department of Chemistry, Teacher's College, Kyungpook University)
  • 박병각 (영남대학교 이과대학 화학과) ;
  • 여환진 (경북대학교 사범대학 화학과)
  • Published : 1985.08.20
Download PDF
⟨ Previous Next ⟩

Abstract

Formation of metal complex is the first step in the many biological actions of metal ions present in the biological systems. In this work the not electron affinity necessary for the formation of such metal complexes has been determined for a series of metal ions. It has been found that excess polarizing strength can be adopted as a measure of electron affinity and trend is the excess polarizing strength is related to Irving-Williams series. Those metal ions having greater than 0.22 in value of excess polarizing strength have been found to show carcinogenicity and other metal ions, which are supposed to be carcinogenic, have shows to have greater than 0. 22 in value of excess polarizing strength, demonstrating that excess polarizing strength could be used to determine if any metal ion possesses carcinogenic activity.

금속이온이 생체내에서 생체성분과 금속착물을 형성하는 것이 여러가지 생물학적 작용의 첫단계로 인정되고 있다. 본 연구에서 금속이온의 착물형성에 중요한 인자로서 과잉편극세기가 순수한 친자성 척도가 됨을 알았으며, 또한 과잉편극세기가 금속착물의 생성상수와 관련된 Irving-Williams계열을 설명할 수 있었다. 실험적으로 발암성이 밝혀진 금속이온의 과잉편극세기의 값이 0.22이상이었으며 나아가서 과잉편극세기의 값이 0.22이상인 금속이온은 발암성을 가질 수 있을 것으로 예측된다. 따라서 이 양을 금속이온의 화학발암성의 척도로 채택할 것을 제안한다.

Keywords

References

  1. Brit. J. Indust. Med. v.8 P.L. Bidstrup
  2. Med. Press & Circ. v.36 G.A. Stephens
  3. Brit. J. Indust. Med. v.18 R.W. Portal
  4. Geol. Soc. Am., Memoir No. v.123 A. Furst
  5. Arch. Indust. Health v.20 F.W. Sunderman(et al)
  6. Cancer Causing Agent L. Winter
  7. cancer v.53 no.2 Yoram Cohen(et al.)
  8. J. of Inorg. Biochem. v.15 P. Zatta(et al.)
  9. Chemistry of Chelation in Cancer A. Furst
  10. Chem. Pharm. Bull. (Tokyo) v.10 M. Ishidate(et al.)
  11. The Jerusalem Symposia on Quantam Chemistry and Biochemistry v.I A. Furst(et al.)
  12. Proc. Nat. Acad. Sci. U.S.A. v.46 A. Szent-Gyorgyi(et al.)
  13. Horizons in Biochemistry C. Huggins
  14. Nature v.169 L.H. Ahrens
  15. An Introduction to the Chemistry of Complex Chemistry A.A. Grinberg
  16. Geochem. cosmochim. Acta v.2 L.H. Ahrens
  17. Periodie correlations R. Rich
  18. J. Chem. Soc. H. Irving;R.J. Williams.
  19. Introduction to Ligan Field B.N. Figgs
  20. Brit. J. Cancer v.1 O. Neubauer
  21. Cancer Res. v.27 M. Kanisawa(et al.)
  22. J. Chrom. Dis. v.23 H.A. Schroeder(et al.)
  23. Bioinorg, Chem. v.9 G.N. Schrauzer(et al.)