Archives of Pharmacal Research

  • 제8권4호
  • /
  • Pages.253-256
  • /
  • 1985
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Antineoplastic natural products and the analogues V - Antitumor Activity of Skullcapflavon II

  • Ryu, Sung-Ho (College of Pharmacy, Chungnam National University) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University) ;
  • Pack, Moo-Young (Department of Biological Science and Engineering, KAIST)
  • 발행 : 1985.12.01
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초록

The effect of skullcapflavon II, 5, 2'- dihydroxy-6, 7, 8, 6'-tetramethoxyflavone, on the growth of transplantable L 1210 and sarcoma 180 tumors in mice was studied. Intraperitional treatment of skullcapflavon II cased a significant (T/C = 166%) and a moderate (T/C = 122 %) prolongations of the life spans of ICR and $BDF_{1}$ mice respectively, which had been intraperitioneally inoculated with sarcoma 180 and L 1210 cells. Peritumoral injection of skullacapflavon II on the solid form of sarcoma 180 in mice inhibited the tumor growth strongly (Inhibition rate = 71%).

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