Studies on Efficacy of Combined Preparation of Crude Drugs(XXIII) -Analgesic, Anticonvulsive, Sedative, Antipyretic Actions of Yangkyuksanwhatang and its Effects on Isolated Ileum and Blood Vessel-

생약복합제제(生藥複合製劑)의 약효연구(藥效硏究) (제13보)(第13報) -양격산화탕(凉膈散火湯)의 진통(鎭痛) 항경련(抗痙攣) 진정(鎭靜) 해열(解熱) 작용(作用) 및 적출(摘出) 장관(腸管) 및 혈관(血管)에 미치는 영향(影響)-

Analgesic, anticonvulsive, sedative and antipyretic actions of Yangkyuksanwhatang which is composed of nine crude drugs including Rehmanniae Radix, and its effects on isolated ileum and blood vessel were investigated. The results of the studies were summerized as follows; 1. Analgesic and antipyretic effects were observed. 2. Suppressive actions were not shown on the convulsion induced by strychnine, but significant effects were noted on the convulsion induced by picrotoxin. 3. A prolongation of anesthetic time induced by pentobarbital sodium was significantly observed. 4. Relaxing actions were noted on the ileum of mice, and also, same effects were recognized on the contraction of the ileum due to acetylcholine chloride and barium chloride. 5. The expansion of blood vessels by relaxation of smooth muscle and hypotensive effects were noted.