Journal of Pharmaceutical Investigation
- Volume 15 Issue 1
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- Pages.40-44
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- 1985
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Studies on Stability of Ftorafur
항암제제(抗癌製劑) 개발(開發)에 관(關)한 연구(硏究) -Ftorafur의 안전성(安定性)에 관(關)한 연구(硏究)-
- Baik, Chia-Sun (College of Pharmacy, Cho Sun University) ;
- Choi, Jun-Shik (College of Pharmacy, Cho Sun University) ;
- Yu, Young-Jong (College of Pharmacy, Cho Sun University)
- Published : 1985.03.20
Abstract
The stability of ftorafur in artificial gastric juice and its major decomposition product were studied quantitatively by the combination of TLC technique and UV-recording spectrophotometry. The decomposition proceeded in first-order reaction. The decomposition rate was accelerated by the increase of temperature. The major decomposition products were identified as 5-fluorouracil. The apparent activation energy for the decomposition was found to he approximately 24.3kcal/mole from Arrhenius plot.
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