Bulletin of the Korean Chemical Society

  • 제5권6호
  • /
  • Pages.215-218
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  • 1984
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis of Nuclophilic Adducts of Thiols (Ⅵ). Addition of L-Cystein to $\beta,\;\beta$-Diethoxycarbonylstyrene Derivatives

  • 발행 : 1984.12.20
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초록

A series of S-(2,2-diethoxycarbonyl-1-phenylethyl)-L-cysteine derivatives (10a-e) were synthesized from the reaction of $\beta$$\beta$-diethoxycarbonylstyrene with L-cysteine in 1:1 aqueous methanol. Thus, S-(2,2-diethoxycarbonyl-1-phenylethyl)-L-cysteine( 10a), S-[2,2-diethoxycarbonyl-1-(3',4'-methylendioxy)ph enylethyl]-L-cysteine (10b), S-[2,2-diethoxycarbonyl-1-(3',4',5'-trimethoxy)phe nylethyl]-L-cyseine (10c), S-[2,2-diethoxycarbonyl-1-(p-hydroxy)phenylethyl] -L-cysteine (10d), S-[2,2-diethoxycarbonyl-1-(p-methoxy)phenylethyl] -L-cysteine (10e) were obtained in moderate to excellent yields. The structure of the adducts was characterized by analytical and spectral data. The effects of pH upon the product yields were also briefly examined.

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참고문헌

  1. J. Amer. Chem. Soc. v.80 J. C. Sheehan;D. H. Yang
  2. Exp. Cell. Res. v.57 G. E. Foley;E. F. Barell;R. A. Adams;H. Lazarus
  3. Br. J. Cancer Res. v.18 K. A. Harrap;D. E. M. Speed
  4. J. Med. Chem. v.13 K. Y. Zee-Cheng;C. C. Cheng
  5. J. Med. Chem. v.15 K. Y. Zee-Cheng;C. C. Cheng
  6. Bull. Korean Chem. Soc. v.2 T. R. Kim;S. Y. Choi
  7. Bull. Korean Chem. Soc. v.4 T. R. Kim;S. Y. Choi;W. S. Choi
  8. FEBS Letters v.30 N. Runsch(et al.)
  9. Carbohydrate Res. v.43 M. Esterbauer
  10. J. Med. Chem. v.20 I. H. Hall;K. H. Lee;E. C. Mar;C. O. Starness
  11. Tetrahedron v.32 H. Esterbauer;A. Ertl;N. Soholz
  12. J. Med. Chem. v.19 B. Paul;W. Korytnyk
  13. FEBS letters v.30 N. Runsch(et al.)
  14. Carbohydrate Res. v.43 M. Esterbauer
  15. J. Med. Chem. v.20 I. H. Hall;K. H. Lee;E. C. Mar;C. O. Starness
  16. Org. Synthesis Coll. v.3