약학회지 (YAKHAK HOEJI)
- 제28권1호
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- Pages.1-10
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- 1984
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Dehydrojuvabione의 전합성
A Total Synthesis of Dehydrojuvabione
초록
A total synthesis of dehydrojuvabione which has high juvenile hormone activity, is described. The kinetic enloate of mesityl oxide is used as nucleophilic synthon for this synthesis. 1,4-Dioxaspiro [4,5] decan-8-carboxaldehyde was treated with kinetic enolate of mesityl oxide to give 8-(1'-hydroxy-5'-methyl-3'-oxo-4'-hexenyl)-1,4-dioxaspiro [4,5] decane. The latter compound was dehydrated. The resulted dienone was treated with lithium dimethylcuprate. After that, appropriate transformation was performed to give dehydrojuvabione.
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