The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Studies on Constituents of the Higher Fungi of Korea(XLVIII) -Nematoxin of Naematoloma fasciculare-

한국산(韓國産) 고등(高等) 균류(菌類)의 성분(威分) 연구(硏究)(제48보)(第48報) -노란다발버섯의 독(毒) 성분(成分) 네마톡신-

  • Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Shim, Mi-Ja (Division of Liberal Arts, Seoul City University)
  • 김병각 (서울대학교 약학대학 미생물약품화학교실) ;
  • 심미자 (서울시립대학 기초과정부)
  • Published : 1984.10.30
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Abstract

To find toxic components in Korean higher fungi, the carpophores of Naematoloma fasciculare which had caused several cases of lethal intoxication were examined for toxicity. The components of high molecular weight were separated by ethanol precipitation and dialysis from the aqueous extract of the carpophores. After the components were freeze-dried, a brown powder was obtained. When a dose of 60mg/kg of this macromolecular fraction was intraperitoneally injected into mice, the mice began to die in six days and a half of them died within seven days. This toxic component was named nematoxin after the genus name of the mushroom.

한국에 야생하는 독버섯의 하나인 노란다발버섯을 물로 가열 추출한 후 추출액에 3배의 에탄올을 첨가하여 고분자 물질을 침전시켰으며 이를 다시 투석하여 정제 하였다. 이것을 냉동 건조하여 분말을 얻었으며 60mg/kg 용량을 백서의 복강내에 주사 하였던 바, 6일 후 부터 사망하기 시작하여 7일째에는 7마리중 4마리가 절명하였다. 이 유독 성분을 "네마톡신"이라 명명하고자 한다.

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