대한약리학회지 (The Korean Journal of Pharmacology)
- 제20권2호
- /
- Pages.73-80
- /
- 1984
- /
- 0377-9459(pISSN)
Higenamine과 그 유도체들이 흰쥐 미토콘드리아 Monoamine Oxidase 활성에 미치는 영향
Effects of Higenamine and Its Derivatives on the Activity of Rat Brain Mitochondrial Monoamine Oxidase
- Suh, Yoo-Hun (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Park, Hae-Young (Department of Pharmacology, College of Medicine, Seoul National University) ;
-
Lim, Jung-Kyoo
(Department of Pharmacology, College of Medicine, Seoul National University) ;
- Park, Chan-Woong (Department of Pharmacology, College of Medicine, Seoul National University)
- 발행 : 1984.12.30
초록
본 연구에서는 higenamine과 그 유도체들이 백서 뇌 미토콘드리아 Monoamine Oxidase(MAO) 의 활성에 미치는 영향에 관하여 관찰하였다. 시험한 화합물들 중에서 심장의 등장성 수축에는 효과를 나타내지 않는 methoxyhigenamine이 가장 5-hydroxytryptamine(5-HT)과 phenylethylamine(PEA)에 대한 MAO의 활성을 가역적으로 억제시켰으며, 그 억제 양상은 각각 pure competitive형과 hyperbolic mixed 형이었다. 이에 5-HT에 대한
The effect of higenamine and its derivatives on the activity of rat bran mitochondrial monoamine oxidase(MAO) was studied. Methoxyhigenamine of drugs tested had no effect on isometric contraction of heart and reversibly inhibited MAO towards 5-hydroxytryptamine(5-HT) and phenylethylamine(PEA) in a pure competitive fashion and in a hyperbolic mixed fashion, respectively, but was found to be relatively MAO-A selective inhibitor, with IC50 value for 5-HT lower ten fold than for PEA. The results suggest that methoxyhigenamine is a reversible, relatively MAO-A specific inhibitor in virto.
키워드