The Korean Journal of Physiology
- 제18권2호
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- Pages.139-150
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- 1984
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- 0300-4015(pISSN)
고양이 회장 평활근의 수축력에 미치는 Vanadate와 Ouabain의 작용
Effect of Vanadate and Ouabain on the Contractile Response of Cat Ileal Muscle
- Lee, Jae-Yang (Department of Physiology, College of Medicine, Busan National University) ;
- Jung, Jin-Sup (Department of Physiology, College of Medicine, Busan National University) ;
- Kim, Yong-Keun (Department of Physiology, College of Medicine, Busan National University) ;
- Lee, Sang-Ho (Department of Physiology, College of Medicine, Busan National University)
- 발행 : 1984.12.30
초록
Vanadate의 회장 평활근에 대한 수축작용이 Na-K-ATPase를 억제하기 때문인지를 구명하기 위하여 Na-K-ATPase를 억제하는 ouabain과의 작용의 차이를 관찰한 결과 다음과 같은 결론을 얻었다. 1) Ouabain에 의해 나타나는 수축은 2중 peak를 나타내었으나 vanadate 의해서는 단일 Peak만을 보였다. 2) Ouabain에 의한 수축은 atropine
Vanadate is a potent inhibitor of Na-K-ATPase. Ouabain, the another specific inhibitor of Na-K-ATPase, induces the contraction in cardiac muscle and smooth muscle. But, some investigators observed the discrepancies between vanadate and ouabain-induced contraction in cardiac muscle. The difference of vanadate and ouabain-induced contraction was investigated in the cat ileal smooth muscle. The following results were obtained. 1) Ouabain-induced contraction was biphasic, but vanadate-induced contraction had one peak. 2) Atropine inhibited ouabain·induced contraction, but did not inhibit vanadate-induced contraction. 3) Changes in external
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