The Korean Journal of Physiology
- Volume 18 Issue 2
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- Pages.117-124
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- 1984
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- 0300-4015(pISSN)
Effect of Cingulate Cortical Ablation on Gastric Acid Secretion and Plasma Gastrin Concentration in Rats
흰쥐의 위산분비 및 혈장 Gastrin농도에 미치는 대상회전 제거의 영향
- Kim, Myung-Suk (Department of Physiology, Catholic Medical College) ;
- Jo, Yang-Hyeok (Department of Physiology, Catholic Medical College) ;
- Kim, Tae-Uk (Department of Physiology, Catholic Medical College) ;
- Choi, Hyun (Department of Physiology, Catholic Medical College)
- Published : 1984.12.30
Abstract
It has been recently reported that cingulate cortex mar facilitate gastric acid secretion, but its facilitatory mechanism on the gastric acid secretion is still unclear. This study was undertaken to investigate the facilitatory mechanism of the cingulate cortex upon gastric acid secretion in rats. Twenty·three male albino rats were divided into the cingulate(N= 13) and the operated control(N= 10) groups. The cingulate group in which cingulate cortex was removed by suction through a slit-shaped opening on each side of, and parallel to, the sagittal suture. In the operated control group, the surgical procedure was ended with the skull opening and the incision of dura mater. The gastric juice was collected via a chronic gastric cannula after 24 hours of fast, with water ad libitum. The juice was collected continuously for 6 hours, starting 3 hours prior to the injection of gastric secretagogue, pentagastrin
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