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The Crystal and Molecular Structure of Thiamphenicol

  • Shin, Whan-chul (Department of Chemistry, College of Natural Sciences, Seoul National University) ;
  • Kim, Sang-soo (Department of Chemistry, College of Natural Sciences, Seoul National University)
  • 발행 : 1983.04.20

초록

The structure of thiamphenicol, one of the congeners of chloramphenicol which is a well-known antibiotic, has been determined by single crystal x-ray diffraction techniques. The crystal structure was determined using diffractometer data obtained by the $2{\theta}:{\omega}$ scan technique with $MoK{\alpha}$ radiation from a crystal having space group symmetry $P2_{1}2_{1}2_{1}$, and unit cell parameters a = 5.779, b = 15.292 and c = 17.322 ${\AA}$ . The structure was solved by direct methods and refined by least squares to an R = 0.070 for the 2116 reflections. The overall V-shaped conformation of thiamphenicol revealed in this study is consistent with those from the crystallographic studies and the proposed models from the theoretical and nmr studies of chloramphenicol. However there is no intramolecular hydrogen bond and the propanediol moiety is fully extended in the thiamphenicol molecule, while the crystal structures of chloramphenicol show the existence of the hydrogen bond between the two hydroxyl groups of the propanediol moiety forming an acyclic ring. All of the thiamphenicol molecules in the crystal are linked by a threedimensional hydrogen bonding network.

키워드

참고문헌

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피인용 문헌

  1. X-ray powder diffraction data for thiamphenicol, C12H15Cl2NO5S vol.31, pp.1, 1983, https://doi.org/10.1017/s0885715615000834