Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Chain Dimensions and Intrinsic Viscosities of Polypeptides in the Helix-Coil Transition Region

  • Jong-Ryul Kim (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Tai-Kyue Ree (Department of Chemistry, Korea Advanced Institute of Science and Technology)
  • Published : 1983.02.20
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Abstract

An equation is derived which correlates the unperturbed dimensions $_0$ of polypeptides with the helical contents in the helix-coil transition region by using a simple model of a polypeptide chain. The model is a chain of connected balls which represent the repeating units, -CO-NH-CHR-, based on the fact that the repeating unit has a plane structure. The changing trend of the expansion factor ${\alpha}_{\eta}$ in the transition region is connected with the helical content $f_H$. The intrinsic viscosities [${\eta}$] of polypeptides are calculated from the unperturbed dimensions and the ${\alpha}_{\eta}$ factors. The above calculated results concerning $_0$ and [${\eta}$] are compared with other authors' theoretical and experimental results. From the comparison, we concluded that our theory explains better the chain dimensional behavior of polypeptides in the helix-coil transition region than others.

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