Journal of Chest Surgery
- 제16권2호
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- Pages.199-212
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- 1983
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- 2765-1606(pISSN)
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- 2765-1614(eISSN)
토끼 동방결절 박동수에 대한 아데노신의 작용
Inhibitory action of adenosine on sinus rate in isolated rabbit SA node
- Chae, Hurn (Department of Thoracic and Cardiovascular Surgery, College of medicine, Seoul National University) ;
- Suh, Kyung-Phlill (Department of Thoracic and Cardiovascular Surgery, College of medicine, Seoul National University) ;
- Kim, Ki-Whan (Department of Physiology College of medicine, Seoul National University)
- Published : 1983.06.01
Abstract
The inhibition/influences of adenine compounds on the heart have been described repeatedly by many investigators, since the first report by Druny and Szent-Gyorgyi [1929]. These studies have shown that adenosine and adenine nucleotides have an over-all effect similar to that of acetylcholine [ACh] by slowing and weakening the heartbeat. The basic cellular and membrane events underlying the inhibitory action of adenosine on sinus rate, however, are not well understood. Furthermore, the physiological role of adenosine in regulation of the heartbeat remains still to be elucidated. Therefore, this study was undertaken in order to examine the response of rabbit SA node to adenosine and to compare the response to that of ACh. Isolated SA node preparation, whole atrial pair, or left atrlal strip was used in each experiment. Action potentials of SA node were recorded through the intracellular glass microelectrodes, which were filled with 3M KCI and had resistance of 30-50 M. All experiments were performed in a bicarbonate-buffered Tyrode solution which was aerated with 3%
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