Studies on the Efficacy of Combined Preparation of Crude Drugs (XV). -Effects of 'Samulanshin-Tang' on the Central Nervous System and Isolated Ileum-

생약복합제제(生藥複合製劑)의 약효연구(藥效硏究) (제15보)(第15報) -사물안신탕(四物安神湯)이 중추신경계(中樞神經系) 및 적출장관(摘出腸管)에 미치는 영향(影響)-

Although the 'Samulanshin-Tang' has been widely used in clinical purposes in the -oriental medicine, its clinical efficacy is only documented for the case of palpitation in the Oriental medical reference. The present experiments were undertaken to investigate the clinical efficacy of 'Samulanshin-Tang' comparing effects with animal experiments and to validate its oriental medicine description. Following results were obtained; 1)Suppressive action was shown on convulsion due to cerebrocortical and diencephalic causes in Fraction I and II, but no such action was noted myelic causes in mice. 2)Sedative, analgesic and antipyretic actions were noted by Fraction III. 3)Relaxing action was shown on the isolated ileum in mice and antagonistic action was seen on acetylcholine and $BaCl_2$-induced contractions of the ilem that the direct action of the intestinal smooth muscle was recognized in mice and rats.