The Korean Journal of Pharmacology (대한약리학회지)
- Volume 19 Issue 2
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- Pages.57-67
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- 1983
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- 0377-9459(pISSN)
Influences of Electrolytes on the Action of Morphine and Naloxone in Guinea-pig Ileum
해명(海冥) 회종편(回腫片)에서 Morphine과 Naloxone 작용(作用)에 미치는 전해질(電解質)의 영향(影響)
- Kwon, Yong-Chon (Dept. of Psychiatry, Jeonbuk National University, Medical School) ;
- Eun, Hong-Bae (Dept. of Psychiatry, Jeonbuk National University, Medical School) ;
- Cho, Kyu-Park (Dept. of Pharmacology, Jeonbuk National University, Medical School)
- Published : 1983.12.30
Abstract
The influence of electrolyte concentrations on the action of morphine and naloxone was studied in the myenteric plexus-longitudinal muscle preparation of guinea-pig ileum to examine whether opiate receptor binding obseved in vitro with homogenates represents binding to the pharmacological receptor. The preparations were suspended in a modified Krebs-Henseleit bicarbonate buffer solution and electrically stimulated at 0.2 Hz. Morphine inhibited electrically evoked contractions; the concentration of morphine required for a 50-percent inhibition was 190 nM. This inhibitory action of morphine was potentiated in a medium containing lower concentrations of :
Guinea-Pig의 myenteric plexus-longitudinal muscle preparation에서 morphine과 naloxone 효과(效果)에 미치는 전해질(電解質)의 영향(影響)을 관찰(觀察)하였다. 표본(標本)은 Krebs-Henseleit bicarbonate tufter solution 으로 채운 organ bath에 현수(懸垂)하고 0.2Hz로 전기자극(電氣刺戟)하였다. Morphine은 전기자극(電氣刺戟)에 의(依)한 근편수축(筋片收縮)을 억제(抑制)하였으며, 이때
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