대한약리학회지 (The Korean Journal of Pharmacology)
- 제19권1호
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- Pages.61-69
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- 1983
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- 0377-9459(pISSN)
고양이에서 체표냉각에 따른 심혈관계 변동에 관한 연구
Cardiovascular Changes of Cat in Hypothermia
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Ahn, Young-Soo
(Department of Pharmacology, Yonsei University College of Medicine) ;
- Ko, Chang-Mann (Department of Pharmacology, Yonsei University College of Medicine) ;
-
Lee, Woo-Choo
(Department of Pharmacology, Yonsei University College of Medicine)
- 발행 : 1983.06.30
초록
Hypothermia is an essential preparatory procedure for cardiac surgery, which lows the metabolic rate and myocardial oxygen demand. However, hypothermia itself is a stress enough to change the tonus of sympathoadrenal system, especially the cardiovascular responses to the catecholamines. It is reported that the positive chronotropic and inotropic response of catecholamines is exaggerated during hypothermia because of decreased norepinephrine uptake at the junctional cleft or decreased catecholamine metabolism. On the other hand, there are evidences of diminished catecholamines responses in low temperature ana further, interconversion of adrenergic receptors is also suggested. Present investigation was planned to observe the cardiovascular changes and its responses to catecholamines during surface hypothermia in cat. Healthy mongrel cats, weighing
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