Synthesis of Iron and Copper Complexes of 2-Formylpyridine Thiosemicarbazone Derivatives, Potential Antitumor Agents

실험 항암제 2-Formylpyridine Thiosemicarbazone유도체의 철 및 동착물의 합성

The iron and copper chelates of 4-dimethylamino-2-formylpyridine thiosemicarbazone, one of the amine substituted derivatives at 4-C of 2-formylpyridine thiosemicarbazones which are known as the more improved potential antitumor agents, have been synthesized to make them more effective than the ligand (denoted as HL) itself. Their ligand-to-metal ratios were 2:1 and 1:1 for the iron and copper chelates, and the data along with those of elemental analysis and IR spectroscopy showed that. the compositions are [$FeI_{2}{\times}2H_{2}SO_{4}$ and [CuL($H_{2}Cl$O)], respectively.